Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Allele and haplotype frequencies for HLA-DQ in Iranian celiac disease patients

(2014) Allele and haplotype frequencies for HLA-DQ in Iranian celiac disease patients. World Journal of Gastroenterology. pp. 6302-6308. ISSN 1007-9327

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Official URL: <Go to ISI>://WOS:000341019000034

Abstract

AIM: To assess the distribution of human leukocyte antigen (HLA)-DQ2 and -DQ8 in Iranian celiac disease (CD) patients and compare them to healthy Iranian controls. METHODS: To predict the HLA-DQA1 and -DQB1 genes, we used six previously reported HLA-tagging single nucleotide polymorphism to determine HLA genotypes in 59 Iranian patients with 'biopsy-confirmed' CD and in 151 healthy Iranian individuals. To test the transferability of the method, 50 cases and controls were also typed using a commercial kit that identifies individual carriers of DQ2, DQ7 and DQ8 alleles. RESULTS: In this pilot study 97 of CD cases (n = 57) and 58 of controls (n = 87) were carriers of HLA-DQ2 and/or HLA-DQ8 heterodimers, either in the homozygous or heterozygous state. The HLA-DQ pattern of these 57 CD patients: heterozygous DQ2.2 (n = 14) and homozygous DQ2.2 (n = 1), heterozygous DQ2.5 (n = 33) and homozygous DQ2.5 (n = 8), heterozygous DQ8 (n = 13) and homozygous DQ8 (n = 2). Two CD patients were negative for both DQ2 and DQ8 (3). CONCLUSION: The prevalence of DQ8 in our CD population was higher than that reported in other populations (25.4). As reported in other populations, our results underline the primary importance of HLA-DQ alleles in the Iranian population's susceptibility to CD. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.

Item Type: Article
Keywords: Human leukocyte antigen typing Validation Susceptibility Celiac disease Iran risk pathogenesis association prevalence diagnosis Gastroenterology & Hepatology
Page Range: pp. 6302-6308
Journal or Publication Title: World Journal of Gastroenterology
Journal Index: ISI
Volume: 20
Number: 20
Identification Number: https://doi.org/10.3748/wjg.v20.i20.6302
ISSN: 1007-9327
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/2196

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