Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Effect of MDR1 polymorphism on multidrug resistance expression in breast cancer patients

(2010) Effect of MDR1 polymorphism on multidrug resistance expression in breast cancer patients. Genetics and Molecular Research. pp. 34-40. ISSN 1676-5680

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Official URL: <Go to ISI>://WOS:000273607300004

Abstract

One of the limitations in the treatment of cancer patients with chemotherapy is the development of multidrug resistance (MDR). A well-known mechanism responsible for drug resistance is over-expression of ABC-transporter genes such as MDR1. This gene encodes p-glycoprotein (P-gp), a transmembrane glycoprotein that transports many hydrophobic substrates and anti-cancer drugs out of the cell. MDR1 gene polymorphisms could alter the expression level of P-gp and consequently result in drug resistance. We investigated a possible association between MDR1 gene C3435T polymorphism and its expression in Iranian breast cancer patients. PCR-RFLP was used for the detection of C3435T single nucleotide polymorphism in 54 breast cancer patients and 50 healthy individuals. The expression level of MDR1 was determined by real-time quantitative PCR. We observed no difference in the frequency of C3435T polymorphism between breast cancer patients and healthy controls. However, there was a significant association between MDR1 expression levels and C3435T polymorphism in the patients. C3435T polymorphism may play a role in inducing drug resistance by altering the expression level of the MDR1 gene.

Item Type: Article
Keywords: Multidrug resistance MDR1 gene C3435T polymorphism Real-time polymerase chain reaction Breast cancer p-glycoprotein expression c3435t polymorphism gene transporters leukemia Biochemistry & Molecular Biology Genetics & Heredity
Page Range: pp. 34-40
Journal or Publication Title: Genetics and Molecular Research
Journal Index: ISI
Volume: 9
Number: 1
Identification Number: https://doi.org/10.4238/vol9-1gmr669
ISSN: 1676-5680
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/2783

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