Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

S100A8/A9: A Janus-faced molecule in cancer therapy and tumorgenesis

(2009) S100A8/A9: A Janus-faced molecule in cancer therapy and tumorgenesis. European Journal of Pharmacology. pp. 73-83. ISSN 0014-2999

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Official URL: <Go to ISI>://WOS:000272748300008


Correlations exist between the abundance of S100 proteins and disease pathologies. Indeed, this is evidenced by the heterodimeric S100 protein complex S100A8/A9 which has been shown to be involved in inflammatory and neoplastic disorders. However, S100A8/A9 appears as a Janus-faced molecule in this context. On the one hand, it is a powerful apoptotic agent produced by immune cells, making it a very fascinating tool in the battle against cancer. It spears the risk to induce auto-immune response and may serve as a lead compound for cancer-selective therapeutics. In contrast, S100A8/A9 expression in cancer cells has also been associated with tumor development, cancer invasion or metastasis. Clearly, there is a dichotomy and future investigations into the role of S100A8/A9 in cancer biology need to consider both sides of the same coin. (C) 2009 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: Apoptotic agent Chemoattractance Growth arrest Immune escape Metastasis Reactive oxygen species Stress response Tumorgenesis calcium-binding proteins ef-hand proteins nf-kappa-b apoptosis-inducing activity squamous-cell carcinoma peritoneal-exudate cells s100 target specificity gene-expression breast-cancer arachidonic-acid Pharmacology & Pharmacy
Page Range: pp. 73-83
Journal or Publication Title: European Journal of Pharmacology
Journal Index: ISI
Volume: 625
Number: 1-3
Identification Number:
ISSN: 0014-2999
Depositing User: خانم مهدیه رضائی پور

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