Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Apoptosis and cancer: mutations within caspase genes

(2009) Apoptosis and cancer: mutations within caspase genes. Journal of Medical Genetics. pp. 497-510. ISSN 0022-2593

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Official URL: <Go to ISI>://WOS:000268541500001

Abstract

The inactivation of programmed cell death has profound effects not only on the development but also on the overall integrity of multicellular organisms. Beside developmental abnormalities, it may lead to tumorigenesis, autoimmunity, and other serious health problems. Deregulated apoptosis may also be the leading cause of cancer therapy chemoresistance. Caspase family of cysteinyl-proteases plays the key role in the initiation and execution of programmed cell death. This review gives an overview of the role of caspases, their natural modulators like IAPs, FLIPs, and Smac/Diablo in apoptosis and upon inactivation, and also in cancer development. Besides describing the basic mechanisms governing programmed cell death, a large part of this review is dedicated to previous studies that were focused on screening tumours for mutations within caspase genes as well as their regulators. The last part of this review discusses several emerging treatments that involve modulation of caspases and their regulators. Thus, we also highlight caspase cascade modulating experimental anticancer drugs like cFLIP-antagonist CDDO-Me; cIAP1 antagonists OSU-03012 and ME-BS; and XIAP small molecule antagonists 1396-11, 1396-12, 1396-28, triptolide, AEG35156, survivin/Hsp90 antagonist shephedrin, and some of the direct activators of procaspase-3.

Item Type: Article
Keywords: endoplasmic-reticulum stress trail-induced apoptosis drug-induced apoptosis induced cell-death ribozyme-mediated inhibition x-linked inhibitor breast-cancer pancreatic-cancer cytochrome-c lung-cancer Genetics & Heredity
Page Range: pp. 497-510
Journal or Publication Title: Journal of Medical Genetics
Journal Index: ISI
Volume: 46
Number: 8
Identification Number: https://doi.org/10.1136/jmg.2009.066944
ISSN: 0022-2593
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/2807

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