Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

The Status of Glutathione Peroxidase, Superoxide Dismutase, Vitamins A, C, E and Malondialdehyde in Patients with Cardiovascular Disease in Zahedan, Southeast Iran

(2009) The Status of Glutathione Peroxidase, Superoxide Dismutase, Vitamins A, C, E and Malondialdehyde in Patients with Cardiovascular Disease in Zahedan, Southeast Iran. Journal of Nutritional Science and Vitaminology. pp. 309-316. ISSN 0301-4800

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Official URL: <Go to ISI>://WOS:000269165500001

Abstract

Growing evidence has demonstrated that oxidative stress and increased altered oxygen utilization contribute to atherogenesis and cardiovascular disease (CVD) progression. Antioxidants protect the body from damage caused by free radicals. The objective of this study was to determine antioxidants status in CVD patients. This cross-sectional study was performed on 71 patients clinically diagnosed with CVD and 63 healthy individuals. Plasma malondialdehyde (MDA) level was measured for lipid peroxidation product and erythrocyte SOD and GPx activities as enzymatic antioxidants. The serum levels of vitamins A and E were assayed using HPLC and vitamin C by the photometric method. Total antioxidant capacity (TAC) was measured using the ferric reducing ability of plasma (FRAP) method. The results showed a significant reduction in antioxidant status (enzymatic and non-enzymatic) with a concomitant increase in the concentrations of lipid peroxidation products in CVD patients. There was a significant inverse correlation among TAC, SOD, GPx and vitamin C with MDA. It can be concluded that the antioxidant defense system plays all important role in preventing the development and progression of CVD with the ability to control oxidative stress.

Item Type: Article
Keywords: oxidative stress antioxidant status lipid peroxidation CVD patients coronary-artery-disease antioxidant defense systems oxidative stress lipid-peroxidation myocardial-infarction dietary antioxidants heart-failure plasma-levels supplementation atherosclerosis Nutrition & Dietetics
Page Range: pp. 309-316
Journal or Publication Title: Journal of Nutritional Science and Vitaminology
Journal Index: ISI
Volume: 55
Number: 4
Identification Number: https://doi.org/10.3177/jnsv.55.309
ISSN: 0301-4800
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/2808

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