Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

The impact of dietary and lifestyle risk factors on risk of colorectal cancer: A quantitative overview of the epidemiological evidence

(2009) The impact of dietary and lifestyle risk factors on risk of colorectal cancer: A quantitative overview of the epidemiological evidence. International Journal of Cancer. pp. 171-180. ISSN 0020-7136

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Official URL: <Go to ISI>://WOS:000266569200022


Colorectal cancer is a major cause of cancer mortality and is considered to be largely attributable to inappropriate lifestyle and behavior patterns. The purpose of this review was to undertake a comparison of the strength of the associations between known and putative risk factors for colorectal cancer by conducting 10 independent meta-analyses of prospective cohort studies. Studies published between 1966 and January 2008 were identified through EMBASE and MEDLINE, using a combined text word and MESH heading search strategy. Studies were eligible if they reported estimates of the relative risk for colorectal cancer with any of the following: alcohol, smoking, diabetes, physical activity, meat, fish, poultry, fruits and vegetables. Studies were excluded if the estimates were not adjusted at least for age. Overall, data from 103 cohort studies were included. The risk of colorectal cancer was significantly associated with alcohol: individuals consuming the most alcohol had 60 greater risk of colorectal cancer compared with non- or light drinkers (relative risk 1.56, 95 CI 1.42-1.70). Smoking, diabetes, obesity and high meat intakes were each associated with a significant 20 increased risk of colorectal cancer (compared with individuals in the lowest categories for each) with little evidence of between-study heterogeneity or publication bias. Physical activity was protective against colorectal cancer. Public-Health strategies that promote modest alcohol consumption, smoking cessation, weight loss, increased physical activity and moderate consumption of red and processed meat are likely to have significant benefits at the population level for reducing the incidence of colorectal cancer. (C) 2009 UICC

Item Type: Article
Keywords: meta-analysis colorectal cancer lifestyle smoking alcohol singapore chinese health 26-year follow-up growth-factor-i cigarette-smoking physical-activity colon-cancer prospective cohort rectal-cancer meat consumption united-states Oncology
Page Range: pp. 171-180
Journal or Publication Title: International Journal of Cancer
Journal Index: ISI
Volume: 125
Number: 1
Identification Number:
ISSN: 0020-7136
Depositing User: خانم مهدیه رضائی پور

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