Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Glutaraldehyde test for rapid diagnosis of pulmonary tuberculosis

(2009) Glutaraldehyde test for rapid diagnosis of pulmonary tuberculosis. International Journal of Tuberculosis and Lung Disease. pp. 601-605. ISSN 1027-3719

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Official URL: <Go to ISI>://WOS:000265424900013

Abstract

OBJECTIVE: To determine the diagnostic value of blood glutaraldehyde gelification time in pulmonary tuberculosis (PTB). DESIGN: We analysed the blood gelification time using 2.5 glutaraldehyde in 83 PTB patients, 46 patients with non-tuberculosis pulmonary disease and 43 healthy subjects. RESULTS: The mean gelification time of PTB patients (556.9 +/- 122.4) is significantly less than non-tuberculosis pulmonary disease (708.0 +/- 100.5) and healthy subjects (821.2 +/- 1.38.3; P < 0.0001). The optimum cut-off point was 615 seconds by receiver operating characteristic curve analysis. The sensitivity, specificity, positive predictive value and negative predictive value were respectively 85.5, 89.1, 93.4 and 77.3 in distinguishing TB from non-PTB patients; and respectively 8S.5, 93.3, 92.2 and 87.4 in distinguishing PTB patients from controls (non-PTB patients and healthy subjects). CONCLUSION: Because many centres lack sputum culture capacity and sophisticated radiology facilities, the glutaraldehyde test in conjunction with other conventional methods of diagnosis (sputum smear for acid-fast bacilli and frontal chest X-ray) could be a rapid, easy, cost-effective and reliable test for the diagnosis of PTB.

Item Type: Article
Keywords: gelification time glutaraldehyde test tuberculosis acid-fast bacilli polymerase chain-reaction direct microscopy improved sensitivity developing-countries smear microscopy sputum Infectious Diseases Respiratory System
Page Range: pp. 601-605
Journal or Publication Title: International Journal of Tuberculosis and Lung Disease
Journal Index: ISI
Volume: 13
Number: 5
ISSN: 1027-3719
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/2816

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