Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Evaluation of the Efficacy of Ribavirin. Therapy on Survival of Crimean-Congo Hemorrhagic Fever Patients: a Case-Control Study

(2009) Evaluation of the Efficacy of Ribavirin. Therapy on Survival of Crimean-Congo Hemorrhagic Fever Patients: a Case-Control Study. Japanese Journal of Infectious Diseases. pp. 11-15. ISSN 1344-6304

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Official URL: <Go to ISI>://WOS:000263186800003

Abstract

The mortality rate resulting from Crimean-Congo hemorrhagic fever (CCHF) has been reported in different epidemics to range from 5 to more than 70. While ribavirin has been recommended as the drug of choice in the treatment of CCHF, no consistent study has unequivocally demonstrated its effectiveness. Using the case-control method, we attempted to evaluate the efficacy of ribavirin in reducing mortality among CCHF cases admitted to Boo-Ali Educational Hospital in Zahedan, Iran, during the years 2000 to 2006. Sixteen deaths among CCHF cases were compared with 47 cases of survival. All patients had a definitive diagnosis based on the results of IgG and IgM capture ELISA tests recorded in their files. Ribavirin therapy for patients who survived had begun on average approximately 24 h earlier than the initiation of ribavirin therapy in the cases of death (P = 0.033), and about 2 days earlier in non-bleeding survivors than in bleeding survivors (P = 0.013). Based on the results of a multivariable analysis, the most important variables found to enhance survival were the time interval between the disease onset and ribavirin prescription (P = 0.004), the time interval between bleeding onset and ribavirin prescription (P = 0.037), and the time interval between disease onset and bleeding onset (P = 0.014). Based on our findings, ribavirin appears to exert a marked effect on disease outcome, especially when it is prescribed within the first 4 days of the disease.

Item Type: Article
Keywords: oral ribavirin outbreak virus risk iran province pakistan turkey Infectious Diseases
Page Range: pp. 11-15
Journal or Publication Title: Japanese Journal of Infectious Diseases
Journal Index: ISI
Volume: 62
Number: 1
ISSN: 1344-6304
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/2829

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