Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

A quantitative study of sodium tungstate protective effect on pancreatic beta cells in streptozotocin-induced diabetic rats

(2008) A quantitative study of sodium tungstate protective effect on pancreatic beta cells in streptozotocin-induced diabetic rats. Micron. pp. 1300-1305. ISSN 0968-4328

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Official URL: <Go to ISI>://WOS:000260873600034

Abstract

Diabetes is a major public health problem. Development of new therapies that are able to improve glycemia management, cure diabetes, and can even protect from it, are of great interest. This study investigated the protective effect of sodium tungstate against STZ-induced beta-cell damages by means of stereological methods. Sixty rats were divided into six groups: control (C), tungstate-treated control (TC), STZ-induced diabetic (D), STZ-induced diabetic rats were treated by sodium tungstate from I week before STZ injection (TDB), food-restricted diabetic (FRD), and diabetic rats treated with sodium tungstate 1 week after STZ administration (TDA). Stereological estimation of pancreas volume, islets volume density, volume-weighted mean islets volume and mass of beta cells, islets, and pancreas and total number of islets were done. Islets volume density, volume-weighted mean islets volume, and mass of beta cells, islets, and pancreas of TDB group was significantly higher than D, FRD and TDA groups (P < 0.001) and was comparable to controls (C and TC groups). Total number of islets, pancreas wet weight and volume did not show any significant changes between these groups (P > 0.05). Results suggested that sodium tungstate preserves pancreatic beta cells from STZ-induced damages and diabetes induction in rats. (C) 2008 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Diabetes mellitus Sodium tungstate Stereology Beta cell weighted mean volume antidiabetic agent glucose-metabolism endocrine pancreas short-term long-term mass normalization mechanism vanadium Microscopy
Page Range: pp. 1300-1305
Journal or Publication Title: Micron
Journal Index: ISI
Volume: 39
Number: 8
Identification Number: https://doi.org/10.1016/j.micron.2008.02.014
ISSN: 0968-4328
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/2835

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