Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Activity of Antioxidant Enzymes in Seminal Plasma and their Relationship with Lipid Peroxidation of Spermatozoa

(2008) Activity of Antioxidant Enzymes in Seminal Plasma and their Relationship with Lipid Peroxidation of Spermatozoa. International Braz J Urol. pp. 485-491. ISSN 1677-5538

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Official URL: <Go to ISI>://WOS:000207705100024

Abstract

Purpose: To determine the activity of seminal plasma catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPX) and their relationship with malondialdehyde (MDA), as a marker of lipid peroxidation, content of spermatozoa and seminal plasma in normozoospermic and asthenozoospermic males. Materials and Methods Semen samples were obtained from 15 normozoospermic and 30 asthenozoospermic men Results. We observed inverse correlations between activities of CAT (k/mL) and SOD (U/mL) in seminal plasma with MDA content of spermatozoa from normozoospermic samples (r = -0.43, p < 0.05 and r = -0.5, p < 0.05, respectively). Significant correlations were observed between total activity CAT (k/total seminal plasma) with total SOD (U/total seminal plasma) and GPX activity (mU/total seminal plasma) in seminal plasma from normozoospermic samples (r = 0.67, p = 0.008 and r = 0.455, p = 0.047, respectively). Furthermore, we found positive correlations between total activities of CAT, SOD and GPX with total content of MDA in seminal plasma (nmoL/total seminal plasma) from normozoospermic samples (r = 0 67, p = 0.003; r = 0.73, p = 0.003; r = 0.74, p = 0.004, respectively). In asthenozoospermic samples, there were no significant correlations observed between activities of CAT (k/mL), SOD (U/mL) and GPX (mU/mL) of seminal plasma with MDA content of spermatozoa. However, we found significant correlations between total activities of CAT (k/total seminal plasma) and SOD (U/total seminal plasma) with total content of MDA in seminal plasma (r = 0.4, p = 0 018 and r = 0.34, p = 0 03, respectively). Conclusion. These findings indicate a protective role for antioxidant enzymes of seminal plasma against lipid peroxidation of spermatozoa in normozoospermic samples.

Item Type: Article
Keywords: catalase, superoxide dismutase glutathione peroxidase semen malondialdehyde Urology & Nephrology
Page Range: pp. 485-491
Journal or Publication Title: International Braz J Urol
Journal Index: ISI
Volume: 34
Number: 4
Identification Number: https://doi.org/10.1590/s1677-55382008000400011
ISSN: 1677-5538
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/2846

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