Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Topical morphine for the treatment of cutaneous leishmaniasis

(2008) Topical morphine for the treatment of cutaneous leishmaniasis. Medical Hypotheses. pp. 81-84. ISSN 0306-9877

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Official URL: <Go to ISI>://WOS:000251929100017


Cutaneous leishmaniasis (CL) is a potentially disfiguring parasitic disease which is endemic in many parts of the world. The evidence for optimal treatment of CL is uncongenial. The development of a compound used for the topical treatment of CL is an attractive option for overcoming the problems of toxic and expensive currently used anti-leishmanial drugs. Easy application is another attraction of topical treatment compared to systemic therapy. Evidence is certainty about a variety of immune responses in the heating process of CL. The immune modulatory effect of morphine also has been known in clinical medicine for decades. Protection against leishmaniasis is dependent upon generation of CD4(+) helper T-cells immune response. There are some evidences that opioids could be members of the cytokine family and the regulation of immune and inflammatory responses is dependent on the functions of cytokines; therefore much effort should be placed on understanding the effect of morphine on cytokine activity. Based on a previous mentioned evidence we suggest that morphine as an immunomodulator could induce the heating process of cutaneous leishmaniasis through inducing the release of a number of cytokines. (C) 2007 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: natural-killer-cells interferon-production opiate receptors opioid receptors amphotericin-b beta-endorphin t-cells lymphocytes efficacy formulations Research & Experimental Medicine
Page Range: pp. 81-84
Journal or Publication Title: Medical Hypotheses
Journal Index: ISI
Volume: 70
Number: 1
Identification Number:
ISSN: 0306-9877
Depositing User: خانم مهدیه رضائی پور

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