Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Pregnancy after renal transplantation: Ten-year single-center experience

(2008) Pregnancy after renal transplantation: Ten-year single-center experience. Transplantation Proceedings. pp. 251-252. ISSN 0041-1345

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Official URL: <Go to ISI>://WOS:000253229500066


There has been an increase in the number of pregnancies among renal transplant recipients. Our experience included 61 pregnancies in 53 patients from January 1997 to April 2007, with 6 patients having multiple pregnancies. Patients were studied for clinical, obstetrical, and perinatal outcomes. The mean patient age was 24.5 years (range, 19-38). They all received living donor kidneys. The mean transplantation-pregnancy interval was 2.7 years (range, 1.7-5.3 years). Immunosuppressive drugs consisted of cyclosporine (CsA), mycophenolate mofetil (MMF), and prednisolone (pred) in 38 patients (72); CsA, azathioprine (AZA), plus pred were used in 15 patients (28). Pregnancy complications were chronic hypertension in 21 patients (40), anemia in 28 (52.6), and urinary tract infection in 18 (34). Twelve patients (22.6) received blood transfusions. Pre-eclampsia was diagnosed in 14 cases (26.4) and renal dysfunction in 11 (20.7) with pre-eclampsia assumed to be the main cause. Three patients (5.6) had graft losses as a result of hemorrhagic shock, sepsis, and eclampsia. Premature rupture of membranes occurred in 6 cases (11.3), and preterm delivery occurred in 14 cases (26.4). Eleven (20.7) newborns were small for gestational age. One club foot and one large facial hemangioma occurred in 2 infants, respectively. One case of neonatal death was registered as a result of excessive prematurity. One mother died due to sepsis. Cesarean section was performed in 24 patients (45.2), the main indications being related to hypertension and fetal distress. There were no significant differences between MMF-treated and AZA-treated patients with respect to clinical, obstetrical, and perinatal outcomes. This group of patients was characterized by a wide range of antenatal and perinatal problems that must be managed in specialized tertiary units to achieve the best results. MMF may be as safe as AZA in pregnancy.

Item Type: Article
Keywords: recipients Immunology Surgery Transplantation
Page Range: pp. 251-252
Journal or Publication Title: Transplantation Proceedings
Journal Index: ISI
Volume: 40
Number: 1
Identification Number:
ISSN: 0041-1345
Depositing User: خانم مهدیه رضائی پور

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