Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

High prevalence of alpha 1 antitrypsin phenotypes in viral hepatitis B infected patients in Iran

(2005) High prevalence of alpha 1 antitrypsin phenotypes in viral hepatitis B infected patients in Iran. Hepatology Research. pp. 292-297. ISSN 1386-6346

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Objective: Hepatitis B virus (HBV) infection is a major global public health problem. Approximately 2 billion people are infected worldwide and more than 350 million of these individuals are chronic carriers of HBV. Approximately 15-40 of infected patients will develop cirrhosis, liver failure, or hepatocellular carcinoma (HCC). Alpha I antitrypsin (AAT) deficiency is one of many factors that may be involved in abnormalities such as liver and lung disease, inflammatory joint diseases, and inflammatory eye diseases. In the present study, the role played by AAT in HBV infected individuals is analyzed. Methods: AAT phenotyping and trypsin inhibitory capacity (TIC) experiments were performed on 281 HBV infected patients who were referred to Tehran and Zahedan Hepatitis Center for a period of 3 years from June 2001 to September 2003. The same tests were performed on 257 individuals who did not suffer from any systemic diseases (control group). The case group was subdivided into three groups: carrier (36.7), chronic (50.5), and cirrhotic (12.8). Results: The results showed that AAT phenotypes, MS, MZ, M(I)Z, and MIS, were significantly higher in the HBV group (p < 0.01). In addition, there was a significant difference in AAT phenotypes (MS, MZ, and MIZ) among inactive carriers and individuals in the chronic and cirrhotic group (p < 0.001). Conclusions: There is a high prevalence of moderate AAT (MS, MIS, and MV) and severely deficient (MZ and M(I)Z) phenotypes in Iranian HBV individuals. In addition, AAT deficiency might be a risk factor for infected HBV individuals progressing from the carrier stage to chronic and cirrhotic stages. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

Item Type: Article
Keywords: alpha 1 antitrypsin viral hepatitis B chronic active hepatitis cirrhosis chronic liver-disease alpha-1 anti-trypsin alpha(1)-antitrypsin deficiency hepatocellular-carcinoma cyto-toxicity cirrhosis alpha1-antitrypsin epidemiology serum prevention Gastroenterology & Hepatology
Page Range: pp. 292-297
Journal or Publication Title: Hepatology Research
Journal Index: ISI
Volume: 33
Number: 4
Identification Number:
ISSN: 1386-6346
Depositing User: خانم مهدیه رضائی پور

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