Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Tuberculous radiculomyelitis: review and presentation of five patients

(2003) Tuberculous radiculomyelitis: review and presentation of five patients. International Journal of Tuberculosis and Lung Disease. pp. 1186-1190. ISSN 1027-3719

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Official URL: <Go to ISI>://WOS:000187029800011


BACKGROUND: The southeast region of Iran is an endemic area for tuberculosis. Tuberculous radiculomyelitis (TBRM) was considered a rare form of parenchymal neurotuberculosis. OBJECTIVE: To analyze the clinical, laboratory and electrophysiological data of patients with TBRM. We report five patients and review the literature. METHOD: We searched Medline since 1966 and reviewed all cases of TBRM, excluding those with Pott's disease. We then evaluated the clinical and electrophysiological data of our patients. RESULTS: Five patients (two men), with a mean age of 25 years, were assessed. The mean duration of symptoms before diagnosis was 4.5 weeks. Three patients had clinical manifestation of tuberculous meningitis (TBM). Diagnosis was based on sputum smear and culture, cerebrospinal fluid (CSF) culture and polymerase chain reaction (PCR) gene amplification of Mycobacterium tuberculosis. Paraparesis or paraplegia, sphincter incontinence and Babinski sign were the main clinical features. CSF analysis was compatible with chronic meningitis. Electromyography showed radiculopathy in all patients and peripheral nerve disease secondary to axonal damage in only three, while myelography showed adhesive arachnoiditis in three. CONCLUSION: Despite the rarity of TBRM, clinical features were well described. To prevent neurological sequelae, early diagnosis and treatment is mandatory. Electrophysiological study may predict the prognosis.

Item Type: Article
Keywords: radiculomyelitis tuberculosis arachnoiditis electromyography Iran spinal meningitides arachnoiditis management neurotuberculosis myelopathy pathology lesion Infectious Diseases Respiratory System
Page Range: pp. 1186-1190
Journal or Publication Title: International Journal of Tuberculosis and Lung Disease
Journal Index: ISI
Volume: 7
Number: 12
ISSN: 1027-3719
Depositing User: خانم مهدیه رضائی پور

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