Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

The L55M polymorphism of paraoxonase-1 is a risk factor for rheumatoid arthritis

(2010) The L55M polymorphism of paraoxonase-1 is a risk factor for rheumatoid arthritis. Genet Mol Res. pp. 1735-41. ISSN 1676-5680

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Abstract

Paraoxonase-1 (PON1) is a high-density lipoprotein-associated enzyme that exhibits antioxidant and antiatherogenic activities. We examined a possible association between T172A (L55M) and T(-107)C polymorphisms and rheumatoid arthritis. These polymorphisms were determined in 88 rheumatoid arthritis patients and 78 healthy subjects, using the tetra-amplification refractory mutation system-PCR method. The prevalence of the PON1 55MM genotype was significantly greater among rheumatoid arthritis patients (17) when compared to control subjects (5.2) (odds ratio (OR) = 3.75; 95 confidence interval (CI) = 1.87-11.8, P = 0.025). In addition, the M allele was more frequent in rheumatoid arthritis patients (40) than in healthy subjects (24.7) (OR = 1.997; 95CI = 1.243-3.210, P = 0.005). There were no significant differences in the -107C/T polymorphism in the promoter sequence of PON1 between rheumatoid arthritis and normal subjects (chi(2) = 0.861, P = 0.650). In conclusion, the PON1 55MM genotype is a risk factor for rheumatoid arthritis.

Item Type: Article
Keywords: Adult Arthritis, Rheumatoid/*genetics Aryldialkylphosphatase/*genetics Female Genetic Predisposition to Disease/genetics Genotype Humans Male Middle Aged Polymerase Chain Reaction Polymorphism, Genetic/*genetics
Page Range: pp. 1735-41
Journal or Publication Title: Genet Mol Res
Journal Index: Pubmed
Volume: 9
Number: 3
Identification Number: https://doi.org/10.4238/vol9-3gmr893
ISSN: 1676-5680
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/2961

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