Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Alpha-1-antitrypsin phenotypes and HLA-B27 typing in uveitis patients in southeast Iran

(2005) Alpha-1-antitrypsin phenotypes and HLA-B27 typing in uveitis patients in southeast Iran. Clin Biochem. pp. 425-32. ISSN 0009-9120 (Print) 0009-9120

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Abstract

OBJECTIVES: Uveitis is an eye disease that affects humans worldwide. Inflammation of the uveal tract is termed uveitis. Alpha-1-antitrypsin (AAT) deficiency is one of many factors that may be involved in abnormalities such as liver and lung disease, inflammatory joint diseases, and inflammatory eye diseases. In this study, the role of AAT in uveitis is analyzed. DESIGN AND METHODS: AAT phenotyping and serum-trypsin inhibitory capacity (S-TIC) experiments were performed on 103 patients who were referred to the ALZAHRA eye center in Zahedan (southeast of Iran). The same experiments were performed on 167 people who did not suffer from any eye or systemic diseases and served as a control group. RESULTS: The results revealed that the frequency of M1S, M2S, M1Z, and MV phenotypes were significantly higher in uveitis patients (P < 0.001). There was no difference in AAT phenotype frequencies between various types of uveitis (P = 0.1). CONCLUSION: AAT deficiency appears to be a risk factor for uveitis in southeast Iran. More investigation is needed to establish potential benefits of AAT phenotyping tests and AAT therapy in the diagnosis and treatment of uveitis cases with unclear etiology.

Item Type: Article
Keywords: Case-Control Studies Ethnic Groups/genetics HLA-B27 Antigen/*genetics Humans Iran Panuveitis/genetics Phenotype Trypsin Inhibitors/blood Uveitis/*genetics Uveitis, Anterior/genetics Uveitis, Posterior/genetics alpha 1-Antitrypsin/*genetics
Page Range: pp. 425-32
Journal or Publication Title: Clin Biochem
Journal Index: Pubmed
Volume: 38
Number: 5
Identification Number: https://doi.org/10.1016/j.clinbiochem.2005.02.006
ISSN: 0009-9120 (Print) 0009-9120
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/3013

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