Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Association Study of TPH1 (rs1800532) and TPH2 (rs4570625) Polymorphisms in Type 1 Bipolar Disorder in Iran

(2019) Association Study of TPH1 (rs1800532) and TPH2 (rs4570625) Polymorphisms in Type 1 Bipolar Disorder in Iran. Gene, Cell and Tissue. ISSN 2345-6841

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Background: Bipolar disorder (BD) has episodes of depression and mania or hypomania. Several studies have been conducted on the role of genes in bipolar disorders and suicidal behaviors, and serotonin-associated genes, Tryptophan hydroxylase (TPH1 and TPH2), are proposed as one of the main effective genetic factors. Methods: In this study, 116 BD patients and 118 age and gender-matched healthy subjects were recruited as the control group. The polymorphisms of THP1 (rs1800532) and TPH2 (rs4570625) genes were identified using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results: There was a positive association of bipolar disorder with CC genotype (P = 0.04) for TPH1 A218C polymorphism, yet not for other genotypes and alleles. There was no association for the genotype and allelic frequency distributions of TPH2-703G/T between bipolar patients and healthy control groups. Conclusions: The TPH1 and TPH2 gene polymorphisms are subjects of many researches. There are contradictions in investigations around the world. These results are in agreement with studies of other populations, yet are different from many studies. There is a need for further investigations.

Item Type: Article
Keywords: Bipolar Disorder; TPH1 Gene; TPH2 Gene; Polymorphism
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Clinical Biochemistry
Journal or Publication Title: Gene, Cell and Tissue
Journal Index: ISC, Not Index
Volume: 5
Number: 4
Identification Number:
ISSN: 2345-6841
Depositing User: خانم مهدیه رضائی پور

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