Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Myocardial Cell Signaling During the Transition to Heart Failure: Cellular Signaling and Therapeutic Approaches

(2019) Myocardial Cell Signaling During the Transition to Heart Failure: Cellular Signaling and Therapeutic Approaches. Comprehensive Physiology. pp. 75-125. ISSN 2040-4603

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Official URL: <Go to ISI>://WOS:000453274100003

Abstract

Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. This review summarizes the signaling pathways implicated in the transition to HF following cardiac injury. In addition, we provide an update on cell death signaling and discuss recent advances in cardiac fibrosis as an independent event leading to HF. Finally, we discuss cell-based therapies and their possible use to avert the deteriorating nature of HF. (c) 2019 American Physiological Society.

Item Type: Article
Keywords: mesenchymal stem-cells angiotensin-aldosterone-system mitochondrial permeability transition activated protein-kinase necrosis-factor-alpha matrix-metalloproteinase inhibition helix transcription factor left-ventricular function smooth muscle actin ii type-1 receptor Physiology
Page Range: pp. 75-125
Journal or Publication Title: Comprehensive Physiology
Journal Index: ISI
Volume: 9
Number: 1
Identification Number: https://doi.org/10.1002/cphy.c170053
ISSN: 2040-4603
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/3086

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