Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

CD73; a key ectonucleotidase in the development of breast cancer: Recent advances and perspectives

(2019) CD73; a key ectonucleotidase in the development of breast cancer: Recent advances and perspectives. J Cell Physiol. ISSN 0021-9541

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Abstract

Tumor cell invasion and metastasis are the definitive cause of mortality in breast cancer (BC). Hypoxia and pro-inflammatory cytokines upregulate the CD73 gene in the tumor microenvironment. Subsequently, CD73 triggers molecular and cellular signaling pathways by both enzymatic and nonenzymatic pathways, which finally leads to breast tumor progression and development. In this paper, we summarize current advances in the understanding of CD73-driven mechanisms that promote BC development and mortality. Furthermore, we evaluate the therapeutic potential of CD73 targeting in BC.

Item Type: Article
Keywords: Cd73 breast cancer ectonucleotidase tumor microenvironment (TME)
Journal or Publication Title: J Cell Physiol
Journal Index: Pubmed
Identification Number: https://doi.org/10.1002/jcp.28187
ISSN: 0021-9541
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/3107

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