Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

The Effect of Ginger Hydroalcholic Extract on Rat Ileal Contraction in Vitro

(2016) The Effect of Ginger Hydroalcholic Extract on Rat Ileal Contraction in Vitro. Zahedan Journal of Research in Medical Sciences. pp. 1-5. ISSN 2383-2894

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Abstract

Background: Ginger is a medicinal plant with wide use around the world which has several therapeutic implications especially in gastrointestinal discomfort such as dyspepsia, flatulence, colic, diarrhea, nausea and vomiting. Objectives: Therefore, given the widespread use of ginger for the treatment of gastrointestinal diseases, in the present study we have investigated the effect of this herbal medicine and underlying mechanism on pre-contracted rat ileum segments. Materials and Methods: In this experimental study, 40 male rat divided to 5 groups (n = 8 in each group) randomly. Groups were consisting: ginger alone, KCl + ginger, carbachol + ginger, pretreated with L-NAME and KCl + ginger, pretreated with verapamil and KCl + ginger. To investigate the mechanism underlying relaxation induced by ginger extract on rat ileum, isolated rat ileum segments were pre-contracted by KCl 120µmol or carbachol 100µmol and then relaxation response induced by ginger hydroalcholic extracts (with 100 or 200 µg/mL of organ bath) was studied in the presence of verapamil (a calcium channel blocker agents) and L-NAME (a nitric oxide synthase inhibitor). Results: Non-cumulative concentrations of ginger extract (100 and 200 µg/mL) was able to decrease contractile responses to KCl (120 µmol/mL of organ bath) and carbachol (100 µmol/mL of organ bath) in a dose dependent manner (P < 0.05). Incubation of tissue with L-NAME (300 µmol/mL) was not able to reduce the relaxation response; however incubation with verapamil inhibited the relaxation response induced by ginger extract. Conclusions: The relaxation response induced by ginger extract in the present study was not mediated by nitric oxide. However calcium channel may contribute to relaxation response.

Item Type: Article
Keywords: Ginger, Ileal Motility, Rat
Subjects: QT Physiology > QT104-172 Human Physiology
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Physiology
Page Range: pp. 1-5
Journal or Publication Title: Zahedan Journal of Research in Medical Sciences
Journal Index: ISC
Volume: 18
Number: 2
Identification Number: https://doi.org/10.17795/zjrms-5984
ISSN: 2383-2894
Depositing User: خانم شهره شهرکی
URI: http://eprints.zaums.ac.ir/id/eprint/3151

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