Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Fabrication of Gelatin Nano-Capsules Incorporate Ferula assa-foetida Essential Oil With Antibacterial and Antioxidant

(2015) Fabrication of Gelatin Nano-Capsules Incorporate Ferula assa-foetida Essential Oil With Antibacterial and Antioxidant. Zahedan Journal of Research in Medical Sciences. pp. 1-4. ISSN 2383-2894

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Abstract

Background: Manufacturing Gelatin nano-capsules merged with Ferula assa-foetida essential oil, antioxidant and antibacterial properties to produce drugs with properties targeted drug delivery to the body. Objectives: In this study, we proved that gelatin nano-capsules grafted with F. assa-foetida essential oil have excellent physical, well as good antioxidant and antibacterial activity, which is suitable for producing nano-capsules of antioxidant antibacterial drug. Materials and Methods: In this experimental study, gelatinnano-capsules were prepared from gelatin solutions (10% w/v) containing F. assa-foetida essential oil (FAO) (2, 4, 6 and 8% w/w), glycerol (25% w/w) as plasticizer and glutaraldehyde (2% w/w) as cross-linker. The morphology, antioxidant and antibacterial properties of the nano-capsules were achieved according to American Society for Testing and Materials. Results: Gelatin nano-capsules exhibited low antioxidant activity while gelatin nano-capsules incorporated with FAO exhibited excellent antioxidant properties. The nano-capsules incorporated with FAO also exhibited excellent antibacterial properties against both Grampositive and Gram-negative bacteria. Conclusions: According to the results, gelatin nano-capsules are good nominations for a variety of antibiotic replacement industrial. The nano-capsules as well as due to the risk of bacterial resistance stay safe. The nano-capsules according to the origin of the whole plant do not have any negative effects on the body.

Item Type: Article
Keywords: Gelatin; Capsules; Ferula assa-foetida; Antioxidant; Antibacterial
Subjects: WC Communicable Diseases > WC 680-950 Tropical and Parasitic Diseases
Divisions: Education Vice-Chancellor Department > Faculty of Pharmacy > Department of Pharmacognosy and Pharmaceutical Biotechnology
Page Range: pp. 1-4
Journal or Publication Title: Zahedan Journal of Research in Medical Sciences
Journal Index: ISC
Volume: 17
Number: 7
Identification Number: https://doi.org/10.17795/zjrms1018
ISSN: 2383-2894
Depositing User: خانم شهره شهرکی
URI: http://eprints.zaums.ac.ir/id/eprint/3162

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