Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Serum Fetuin-A and Adipsin Levels in Type II Diabetes Patients

(2019) Serum Fetuin-A and Adipsin Levels in Type II Diabetes Patients. International Journal of High Risk Behaviors and Addiction.

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Abstract

Background: Fetuin-A is a glycoprotein known as a biomarker for diabetes risk. Adipsin or complement factor D (CFD) plays a role in glucose tolerance, and metabolism. Objectives: This study aimed to investigate the concentration of fetuin-A and adipsin in patients with type 2 diabetes mellitus (T2DM) and healthy subjects. Patients and Methods: This case–control study was carried out on 43 patients with T2DM and 41 healthy subjects. Biochemical parameters were determined. Fetuin-A and adipsin levels were measured using ELISA kits. Lipid profile and biochemical factors were measured by spectrophotometric methods. Results: The results showed a trend toward lower fetuin-A and CFD concentrations between the two groups (P < 0.05). There was a significant correlation between the levels of fetuin- A and adipsin (P < 0.0001), FBS and HbA1C (P = 0.02), FBS and creatinine (P = 0.03), and BUN (P < 0.001).There was significant differences according to biochemical levels between the two groups (P < 0.001). Conclusions: The findings suggest that fetuin-A and adipsin levels were decreased in T2DM. It seems that the result of fetuin-A and adipsin levels in the diabetes depends on numerous vague factors. Nevertheless, in comparison with published data the changes of fetuin and adipsin levels in patients with T2DM indicate a complex but not complete role of fetuin-A and adipsin in the pathogenesis of T2DM.

Item Type: Article
Keywords: Fetuins Complement Factor D, Human Biomarkers Diabetes Mellitus, Type 2 (T2DM)
Subjects: QZ Pathology > QZ 40-105 Pathogenesis. Etiology
WB Practice of Medicine > WB 141-293Diagnosis
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Nutrition
Journal or Publication Title: International Journal of High Risk Behaviors and Addiction
Journal Index: Scopus, ISC
Identification Number: https://doi.org/10.5812/ijhrba.91963
Depositing User: خانم صدیقه معلمی
URI: http://eprints.zaums.ac.ir/id/eprint/3594

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