Abstract

We have read with great interest the recent article by Fazli and Ghorbian describing their study about the “Association study of non-coding RNA miR-499 and miR196a2 gene polymorphisms with the risk of idiopathic recurrent pregnancy loss” (1). We would like to thank the authors for sharing their valuable experience with non-coding RNA gene polymorphisms with the risk of idiopathic recurrent pregnancy loss (RPL). The authors found that the polymorphism of themiR-499 gene had a statistically significant association with the risk of RPL, unlike miR-196a2. They concluded that themiR-499 gene encoding regionmay be contributed as a genetic predisposition factor to RPL. However, the role of miR-499 and miR196a2 gene polymorphisms in patients with RPL remains unclear