Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

LMO1 polymorphisms and the risk of neuroblastoma: Assessment of meta-analysis of case-control studies

(2019) LMO1 polymorphisms and the risk of neuroblastoma: Assessment of meta-analysis of case-control studies. J Cell Mol Med. ISSN 1582-1838

Full text not available from this repository.

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/?term=LMO1+pol...

Abstract

Neuroblastoma (NB), a neuroendocrine tumour, is one of the most prevalent cancers in children. The link between LMO1 polymorphisms and NB has been investigated by several groups, rendering inconclusive results. Here, with this comprehensive systematic review and up-to-date meta-analysis, we aim to distinctively elucidate the possible correlation between LMO1 polymorphisms and NB susceptibility. Eligible studies were systematically researched and identified using PubMed, Web of Science and Scopus databases up to 10 February 2019. Odds ratios (ORs) and 95 confidence intervals (CIs) were calculated to assess the strength of the associations. Our findings revealed that rs110419 and rs2168101 polymorphisms were significantly associated with a decreased risk of NB in all genetic models. In addition, the rs4758051 variant appeared protective against NB in homozygous, dominant and allele genetic models, whereas the rs10840002 variant markedly decreased the risk of NB in the allele model. In contrast, the rs204938 polymorphism showed a positive association with NB susceptibility in allele genetic models. In summary, our meta-analysis is the first to provide clear evidence of an association between specific polymorphisms of LMO1 and susceptibility to NB. Of note, additional larger well-designed studies would be helpful to further evaluate and confirm this association.

Item Type: Article
Keywords: Lmo1 meta-analysis neuroblastoma polymorphism
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Journal or Publication Title: J Cell Mol Med
Journal Index: Pubmed
Identification Number: https://doi.org/10.1111/jcmm.14836
ISSN: 1582-1838
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/3612

Actions (login required)

View Item View Item