Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Association between COX-2 and 15-PGDH polymorphisms and SLE susceptibility

(UNSPECIFIED) Association between COX-2 and 15-PGDH polymorphisms and SLE susceptibility. International Journal of Rheumatic Diseases. p. 6. ISSN 1756-1841

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Abstract

Aims Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease. Prostaglandins E2 (PGE2), the product of the cyclo-oxygenase 2 (COX-2) enzyme, has critical roles in the etiology of autoimmune diseases. PGE2 level is controlled by a balance between its synthesis mediator (COX-2 enzyme) and its catabolic key enzyme (15-hydroxyprostaglandin dehydrogenase 15-PGDH enzyme). In the present study, the associations of genotypic polymorphisms in COX-2 and 15-PGDH with SLE were investigated. Methods One hundred and sixty SLE patients and 160 healthy controls participated in the study. The polymerase chain reaction - restriction fragments length polymorphism method was used for genotyping. The COX-2 rs2745557 G/A and 15-PGDH rs8752 G/A polymorphisms were investigated. Results Regarding the COX-2 rs2745557 single nucleotide polymorphism, there was no significant association between COX-2 rs2745557 polymorphism and SLE. However, the dominant models showed a marginally significant relation (P = .048, odds ratio = 0.63, 95% CI = 0.4-1.0). Regarding GA genotype of 15-PGDH rd8752 polymorphism, there was a significant difference between two groups with a 4.5-fold increase in SLE development (P = .0001). The frequency of the A allele was higher in SLE patients than that in controls, showing a 1.4-fold increase in SLE development (P = .018). Conclusion All results showed the protective effects of the dominant model of COX-2 rs2745557 polymorphism and risk factor of 15-PGDH rs8752 polymorphism on SLE development.

Item Type: Article
Keywords: 15-PGDH COX-2 polymorphism systemic lupus erythematosus systemic-lupus-erythematosus single nucleotide polymorphism 15-hydroxyprostaglandin dehydrogenase rheumatoid-arthritis cyclooxygenase-2 polymorphisms expression risk gene pathogenesis cells Rheumatology
Page Range: p. 6
Journal or Publication Title: International Journal of Rheumatic Diseases
Journal Index: ISI
Identification Number: https://doi.org/10.1111/1756-185x.13808
ISSN: 1756-1841
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/3832

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