Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Effects of green tea or green tea catechin on liver enzymes in healthy individuals and people with nonalcoholic fatty liver disease: A systematic review and meta-analysis of randomized clinical trials

(UNSPECIFIED) Effects of green tea or green tea catechin on liver enzymes in healthy individuals and people with nonalcoholic fatty liver disease: A systematic review and meta-analysis of randomized clinical trials. Phytotherapy Research. p. 12. ISSN 0951-418X

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Abstract

The therapeutic potential of green tea as a rich source of antioxidants and anti-inflammatory compounds has been investigated by several studies. The present study aimed to systematically review and analyze randomized clinical trials (RCTs) assessing the effects of green tea, catechin, and other forms of green tea supplementation on levels of liver enzymes. PubMed, SCOPUS, EMBASE, and Cochrane databases were searched until February 2019. All RCTs investigating the effect of green tea or its catechin on liver enzymes including alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and bilirubin were included. A total of 15 RCTs were included. The overall effect of green tea on liver enzymes was nonsignificant (ALT Standardized mean difference (SMD)= -0.17, CI -0.42 to 0.08, p = .19, AST SMD = -0.07, CI -0.43 to 0.29, p = .69, and ALP SMD = -0.17, CI -0.45 to 0.1, p = .22). However, subgroup analyses showed that green tea reduced the levels of liver enzymes in participants with nonalcoholic fatty liver disease (NAFLD) but in healthy subjects, a small significant increase in liver enzymes was observed. In conclusion, the results of this study suggest that the effect of green tea on liver enzymes is dependent on the health status of individuals. While a moderate reducing effect was observed in patients with NAFLD, in healthy subjects, a small increasing effect was found.

Item Type: Article
Keywords: green tea liver enzyme meta-analysis hormone-binding globulin double-blind epigallocatechin gallate oxidative stress obese women extract supplementation hepatotoxicity intervention testosterone Pharmacology & Pharmacy
Page Range: p. 12
Journal or Publication Title: Phytotherapy Research
Journal Index: ISI
Identification Number: https://doi.org/10.1002/ptr.6637
ISSN: 0951-418X
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/3835

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