Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Two novel bipyridine-based cobalt (II) complexes: synthesis, characterization, molecular docking, DNA-binding and biological evaluation

(UNSPECIFIED) Two novel bipyridine-based cobalt (II) complexes: synthesis, characterization, molecular docking, DNA-binding and biological evaluation. Journal of Biomolecular Structure & Dynamics. p. 15. ISSN 0739-1102

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Abstract

Bipyridine derivatives have shown different applications in chemistry such as electron transfer, catalysis, biological systems and artificial photosynthesis. Two cobalt(II) complexes with formula Co(5,5 '-dmbipy)(2)(NCS)(2)(1) and Co(5,5 '-dmbipy)(3) Co(NCS)(4)(2) were prepared. The metal complexes 1 and 2 were characterized through FT-IR, electronic absorption, elemental analysis and H-1-NMR. The interaction of complexes 1 and 2 with FS-DNA was investigated by fluorescence, UV-Vis and gel electrophoresis. The antibacterial properties have been studied in vitro against two gram-negative and two gram-positive standard bacterial strains. The synthesized complexes were further investigated against MCF-7 cells at 25, 50, 100 and 200 mu M. The results revealed that the metal complexes can bind effectively to FS-DNA. The measured thermodynamic factors (Delta H degrees, Delta S degrees and Delta G degrees) displayed that hydrogen bonding, van der Waals forces (for DNA-compound 1) and electrostatic binding (for DNA-compound 2) are the most important interactions. The binding forces in metal complexes 1 and 2 are spontaneous as suggested by the negative Delta G degrees. Specific viscosity of FS-DNA remained without significant changes while the concentration of complexes 1 and 2 increased. The results of molecular docking with FS-DNA illustrate the binding sites and binding modes that are in acceptable agreement with experimental results. The biological results determined that complexes 1 and 2 exhibit antibacterial activities that are better than those shown for their corresponding metal salt and free ligand. The target compounds showed low-to-moderate cytotoxicity activities. The obtained results revealed that the synthesized complexes are stronger antibacterial agents against the gram-positive than gram-negative bacteria. In the present study, for the first time we reported two Co(II) complexes bearing 5,5 '-dimethyl-2,2 '-bipyridine ligands. Communicated by Ramaswamy H. Sarma

Item Type: Article
Keywords: Co(II) complex 5 5 '-dimethyl-2 2 '-bipyridine DNA-binding cytotoxicity antibacterial activity mixed-ligand complexes crystal-structure spectral characterization antimicrobial activity palladium(ii) complex cytotoxic activity copper(ii) antibacterial 1,10-phenanthroline acid Biochemistry & Molecular Biology Biophysics
Page Range: p. 15
Journal or Publication Title: Journal of Biomolecular Structure & Dynamics
Journal Index: ISI
Identification Number: https://doi.org/10.1080/07391102.2020.1713893
ISSN: 0739-1102
Depositing User: خانم مهدیه رضائی پور
URI: http://eprints.zaums.ac.ir/id/eprint/3850

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