Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

An Updated Review of Methods, Challenges, and Future Perspectives of Circulating Tumor Cell Isolation: Focusing on the Use of Nanomaterials

(2020) An Updated Review of Methods, Challenges, and Future Perspectives of Circulating Tumor Cell Isolation: Focusing on the Use of Nanomaterials. Gene, Cell and Tissue. pp. 2-1. ISSN 2345-6841

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Abstract

Tumor dormancy is defined as a “steady state” where circulating tumor cells (CTCs) are present in patients but do not form a large vascularized tumor. This is due to the absence of stimulatory signals or prolonged activation of suppressive signaling pathways (1). These metastatic cells have been partially accounted for tumor recurrence even years after initial therapies (2). Hence, as hallmarks of tumor progression, CTCs supply beneficial information about single tumors and involved mechanisms by which these cells shed from the original tumor site (3). Although different technologies have been proposed for CTC isolation, nanomaterials have a good potential in overcoming this hurdle. The cell capturing abilityandunique structure of biomaterials may provide insights for discovering nextgeneration treatments against metastatic tumors.

Item Type: Article
Keywords: Circulating Tumor Cells, Dormancy, Nanomaterials
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 300-560 Cell Biology and Genetics
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Molecular Medicine and Genetics
Page Range: pp. 2-1
Journal or Publication Title: Gene, Cell and Tissue
Journal Index: ISC
Volume: 7
Number: 2
Identification Number: https://doi.org/10.5812/gct.102074.
ISSN: 2345-6841
Depositing User: خانم شهره شهرکی
URI: http://eprints.zaums.ac.ir/id/eprint/4008

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