Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

SNPs in the 3 '-untranslated region ofSLC30A8confer risk of type 2 diabetes mellitus in a south-east Iranian population: Evidences from case-control and bioinformatics studies

(UNSPECIFIED) SNPs in the 3 '-untranslated region ofSLC30A8confer risk of type 2 diabetes mellitus in a south-east Iranian population: Evidences from case-control and bioinformatics studies. Journal of Diabetes and Metabolic Disorders. p. 10.

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Abstract

Background Type 2 diabetes mellitus (T2DM) is a heterogenic disease with increasing incidence. TheSLC30A8gene encodes an islet zinc transporter (ZnT8), and its variants have been associated with glucose and pro-insulin levels. This study was aimed to examine the effects of a missense variant (rs13266634 C/T), and two 3'UTR variants (rs2466294 C/G and rs2466293 T/C) inSLC30A8gene on T2DM risk in a south-east Iranian population. Methods In this experiment, 450 patients diagnosed with T2DM and 453 healthy subjects from the same geographic area were enrolled. Genotypes were amplified using the ARMS-PCR method.In silicoanalyses were performed to determine the effects of the variants on the local structure of mRNA, splicing patterns, and potential miRNA-gene interactions as well. Results Significant differences were noticed between cases and controls regarding the genotypic and allelic distribution of the studied variants. As regards rs2466293 and rs2466294 variants, enhanced risk of T2DM was found under allelic, dominant, recessive, and codominant models (OR > 1). Besides, different genetic models of rs13266634 were associated with decreased risk of T2DM (OR < 1). Bioinformatics analyses indicated that the rs2466293 variant might influence the binding of some miRNAs, while the G-allele of rs2466294 decreased the stability ofSLC30A8-mRNA. Conclusions In our population, both SNPs in the 3 '-untranslated region ofSLC30A8increased the risk of T2DM, while the rs13266634 variant showed a protective association against T2DM susceptibility. Investigating the effects of other variants in this gene or other ZnTs can further indicate such associations in subjects from the same ethnicity.

Item Type: Article
Keywords: Diabetes mellitus Gene Polymorphism slc30a8 rs13266634 polymorphism zinc transporter gene polymorphism association variants znt8 Endocrinology & Metabolism
Page Range: p. 10
Journal or Publication Title: Journal of Diabetes and Metabolic Disorders
Journal Index: ISI
Identification Number: https://doi.org/10.1007/s40200-020-00590-5
Depositing User: مهندس مهدی شریفی
URI: http://eprints.zaums.ac.ir/id/eprint/4746

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