Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

The relationships between maternal and placental polymorphisms of miR-196a2 and miRNA-499 genes and preeclampsia

(UNSPECIFIED) The relationships between maternal and placental polymorphisms of miR-196a2 and miRNA-499 genes and preeclampsia. British Journal of Biomedical Science. p. 5. ISSN 0967-4845

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Background miRNAs are small non-coding RNAs with potential roles in the complications of pregnancy. We hypothesised links between polymorphisms in miRNA-196a2 and miRNA-499 in maternal blood and the placentas of patients with preeclampsia. Methods The blood of 315 women with preeclampsia and 317 controls and the placentas of 103 PE and 133 healthy women were collected. The genotyping of both polymorphisms was performed by PCR-RFLP. Results The maternal blood rs11614913 was unrelated to preeclampsia in genotype and allele models, but in placental tissue, the CT (odds ratio 95% CI 0.5 0.3-0.9, p = 0.018) and TT (0.4 0.2-0.9] p = 0.033) genotypes alone and together (CT+TT v CC 0.5 0.3-0.8 p = 0.009), and the T allele (0.6 0.4-0.9, p = 0.019) were associated with lower risk of preeclampsia. The maternal blood rs3746444 CC genotype was more frequent in preeclampsia (2.2 1.2-3.8 p = 0.008) and the recessive model (CC v TC+TT) was also significant (1.9 1.1-3.3, p = 0.018), as was the C allele (1.4 1.1-1.7 p = 0.014). In placental tissue, the increase in the frequency of the CC genotype was marginally significant (2.4 1.0-5.8 p = 0.046). The maternal or placental miRNA-196a2 rs11614913 and miRNA-499 rs3746444 polymorphisms were unrelated to the severity of preeclampsia. Conclusion The placental but not maternal miRNA-196a2 rs11614913 variant could be a protective factor for preeclampsia predisposition in all models except the recessive model. The maternal/placental rs3746444 CC genotype was in association with higher preeclampsia risk.

Item Type: Article
Keywords: miRNA-196a2 miRNA-499 polymorphism placenta preeclampsia micrornas association risk rnas Medical Laboratory Technology
Page Range: p. 5
Journal or Publication Title: British Journal of Biomedical Science
Journal Index: ISI
Identification Number:
ISSN: 0967-4845
Depositing User: مهندس مهدی شریفی

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