Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

The Relationship Between Malnutrition and Liver Enzymes inHospitalized Children in Zahedan: A Case-control Study

(2021) The Relationship Between Malnutrition and Liver Enzymes inHospitalized Children in Zahedan: A Case-control Study. Zahedan Journal of Research in Medical Sciences. ISSN e: 2383-2894

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Abstract

Background:Malnutrition causes nutritional, metabolism, and biochemical disorders and finally leads to mortality. Several stud-ies have highlighted that serum liver enzymes are increased in patients with malnutrition.Objectives:This study aimed to evaluate the relationship between malnutrition and liver enzymes in hospitalized children in Za-hedan.Methods:This case-control study was conducted among 145 hospitalized children under six years old, including 74 cases and 71controls. The case group was diagnosed with malnutrition according to weight for age indices (Z-Score < -2SD), and controls weredetermined based on the following indices (Z-Score > -2SD) of classification of WHO 2006 growth standards. Serum was isolated af-ter taking blood from the samples. Then liver enzymes, including AST, ALP, and ALT, were measured by spectrophotometric method.Results:A total of 145 subjects were enrolled that consisted of 74 cases and 71 controls. No significant difference was observed inserum liver markers, including AST, ALT, and ALP between the two groups, However, the level of AST, ALT, and ALP was higher thanthe standard level. There was a significant correlation between AST with ALT (r = 0.74, P < 0.001), and ALP (r = 0.27, P = 0.03).Conclusions:The findings indicated that there was no significant alteration in enzyme markers in the two groups. However, ASTand ALT levels increased, and ALP levels decreased compared with the control. Different degrees of malnutrition, including mild,moderate, and severe, can probably change the levels of hepatic enzymes in under-nourished children. Alteration of these liverenzymes could be due to the metabolic modification, which can be the result of protein deficiency

Item Type: Article
Keywords: Malnutrition, Enzymes, Alanine Aminotransferase, Aspartate Aminotransferase, Alkaline Phosphatase
Subjects: QU Biochemistry. Cell Biology and Genetics > QU 145-220 Nutrition. Vitamins
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Department of Basic Science > Department of Nutrition
Journal or Publication Title: Zahedan Journal of Research in Medical Sciences
Journal Index: ISC, Not Index
Volume: 23
Number: 1
Publisher: Kowsar
Identification Number: https://doi.org/10.5812/zjrms.102994.
ISSN: e: 2383-2894
Depositing User: خانم دنیاداری مهدیه
URI: http://eprints.zaums.ac.ir/id/eprint/5359

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