Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

The effect of low serum calcium level on the severity and mortality of Covid patients: A systematic review and meta-analysis

(UNSPECIFIED) The effect of low serum calcium level on the severity and mortality of Covid patients: A systematic review and meta-analysis. Immunity Inflammation and Disease. p. 10.

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Abstract

Introduction: Imbalances of various electrolytes, including calcium, are associated with the prognosis of Covid disease. This study investigated the relationship between serum calcium and clinical outcomes in patients with COVID-19. Method: This study is a systematic review and meta-analysis by searching PubMed, Scopus, web of sciences until August 2021 using the keywords COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID, coronavirus disease, SARS-COV-infection. 2, SARS-COV-2, COVID19, calcium, calcium isotopes, calcium radioisotopes, hypercalcemia, and hypocalcemia were performed. Heterogeneity of studies was investigated using I-2 index, data were analyzed using meta-analysis (random effects model) with Comprehensive Meta-Analysis Software software. Results: Finally, 25 articles were included in the study. Clinical data from 12 articles showed that 59 (95 confidence interval CI: 0.49-0.68) of people with COVID-19 have hypocalcemia. The results of meta-analysis showed that hypocalcemia was significantly associated with severity of the disease (p = .002), mortality in patients with COVID-19 (odds ratio OR = 6.99, 95% CI: 2.71-17.99), number of hospitalization days (p < .001) and admission to the intensive care unit (OR = 5.09, 95% CI: 2.14-12.10). The results also showed that there is a direct relationship between low serum calcium levels with increasing D-dimer levels (p = .02) and decreasing lymphocyte counts (p = .007). Conclusion: Based on the results of meta-analysis in people with lower calcium, mortality and complications are higher, therefore, serum calcium is a prognostic factor in determining the severity of the disease. Consequently, it is suggested that serum calcium levels should be considered in initial assessments.

Item Type: Article
Keywords: calcium COVID-19 hypocalcemia SARS-CoV-2 systematic review vitamin-d hypocalcemia disease Immunology
Page Range: p. 10
Journal or Publication Title: Immunity Inflammation and Disease
Journal Index: ISI
Identification Number: https://doi.org/10.1002/iid3.528
Depositing User: مهندس مهدی شریفی
URI: http://eprints.zaums.ac.ir/id/eprint/5373

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