Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

The Iranian Study of Opium and Cancer (IROPICAN): Rationale, Design, and Initial Findings

(2021) The Iranian Study of Opium and Cancer (IROPICAN): Rationale, Design, and Initial Findings. Archives of Iranian Medicine. pp. 167-176. ISSN 1029-2977

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Background: The International Agency for Research on Cancer (IARC) recently classified opium use as a Group 1 carcinogen. However, much remains to be studied on the relation between opium and cancer. We designed the Iranian Opium and Cancer (IROPICAN) study to further investigate the association of opium use and cancers of the head and neck, bladder, lung, and colon and rectum. In this paper, we describe the rationale, design, and some initial results of the IROPICAN Study. Methods: The IROPICAN is a multi-center case-control study conducted in 10 provinces of Iran. The cases were all histologically confirmed and the controls were selected from hospital visitors who were free of cancer, were not family members or friends of the cancer patients, and were visiting the hospital for reasons other than their own ailment. The questionnaires included detailed questions on opium use (including age at initiation, duration, frequency, typical amount, and route), and potential confounders, such as tobacco use (e.g., cigarettes, nass and water-pipe), and dietary factors. Biological samples, including blood and saliva, were also collected. Results: The validation and pilot phases showed reasonably good validity, with sensitivities of 70 and 69 for the cases and controls, respectively, in reporting opium use. The results also showed excellent reliability, with intra-class correlation coefficients of 0.96 for ever opium use and 0.88 (95 CI: 0.80, 0.92) for regular opium use. In the main phase, we recruited 3299 cancer cases (99 response rate) and 3477 hospital visitor controls (89 response rate). The proportion of ever-use of opium was 40 among cases and 18 among controls. Conclusion: The IROPICAN study will serve as a major resource in studies addressing the effect of opium on risk of cancers of the head and neck, bladder, lung, and colon and rectum.

Item Type: Article
Keywords: Bladder cancer Colorectal cancer Head and neck cancer Lung cancer Opium Protocol emerging risk-factor esophageal cancer lung-cancer population golestan prevalence smoking tobacco cohort General & Internal Medicine
Page Range: pp. 167-176
Journal or Publication Title: Archives of Iranian Medicine
Journal Index: ISI
Volume: 24
Number: 3
Identification Number:
ISSN: 1029-2977
Depositing User: مهندس مهدی شریفی

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