Repository of Research and Investigative Information

Repository of Research and Investigative Information

Zahedan University of Medical Sciences

Prevalence of Idiopathic Peptic Ulcer in Southeastern Iran

(2021) Prevalence of Idiopathic Peptic Ulcer in Southeastern Iran. Zahedan Journal of Research in Medical Sciences. ISSN e: 2383-2894

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Background: The idiopathic peptic ulcers (IPU) or non-Helicobacter pylori, non-steroidal anti-inflammatory drug non-NSAIDs associated peptic ulcers are a serious therapeutic challenge. The prevalence of IPU is increasing in some parts of the world. Objectives: This study aimed to determine the prevalence of IPU in southeastern Iran. Methods: In this cross-sectional study, a total of 367 patients with active peptic ulcer were diagnosed by endoscopy between Jan 2018 and Feb 2019. The patients were assessed for history of medication use (including NSAIDs) in the past month, smoking, alcohol, as well as a complete history of health problems related to underlying disease such as cardiopulmonary, hepatic, renal problems, and chronic pancreatitis. Biopsy samples from antrum were performed for rapid urease test (RUT), and if RUT was negative, then biopsies were sent for histopathology. If both RUT and pathologic findings were negative for H. pylori, in patients who had treatment for H. pylori eradication, anti-H. pylori IgG antibody of blood samples was assessed. Patients were considered infected with H. pylori if any of the diagnostic tests had a positive result. Results: According to the results, 336 (91.3%) cases had at least one of the two main etiologic factors (H. pylori and NSAIDs) for peptic ulcer. While 323 (87.7%) patients were H. pylori-positive, 45 (12.3%) patients were H. pylori-negative. However, out of 45 H. pylori-negative cases, 13 patients had a positive history of using NSAIDs, and 32 (8.69%) patients were IPU. Conclusions: Our study showed that both H. pylori infection and NSAIDs use remain the main cause of peptic ulcers, and the prevalence of IPU is relatively high in Zahedan.

Item Type: Article
Keywords: Helicobacter pylori, Idiopathic, Non-Steroidal Anti-Inflammatory Drugs, NSAIDs, Ulcer, Iran
Subjects: WI Digestive System > WI 190-260 Gastrointestinal Tract
WI Digestive System > WI 600-650 Anus. Rectum
Divisions: Education Vice-Chancellor Department > Faculty of Medicine > Departments of Clinical Sciences > Department of Internal
Journal or Publication Title: Zahedan Journal of Research in Medical Sciences
Journal Index: ISC
Volume: 23
Number: 4
Publisher: kowsar
Identification Number:
ISSN: e: 2383-2894
Depositing User: خانم دنیاداری مهدیه

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